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目的探讨基质金属蛋白酶-2(MMP-2)和组织基质金属蛋白抑制剂-2(TIMP-2)在大肠癌组织中的表达及其意义。方法应用免疫组织化学SP法对60例大肠癌组织MMP-2和TIMP-2表达情况进行检测。结果MMP-2和TIMP-2在大肠癌组织中表达的阳性率分别为64.3%和30.3%。MMP-2的表达与大肠癌的病理分期和淋巴转移呈正相关(P<0.05),而TIMP-2的表达与其呈负相关,MMP-2和TIMP-2的表达呈负相关(P<0.05)。结论MMP-2和TIMP-2的表达与大肠癌的病理分期和淋巴转移密切相关,可作为判断大肠癌生物学行为的参考指标。
Objective To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in colorectal cancer. Methods The expression of MMP-2 and TIMP-2 in 60 cases of colorectal cancer was detected by immunohistochemical SP method. Results The positive rates of MMP-2 and TIMP-2 expression in colorectal cancer tissues were 64.3% and 30.3%, respectively. The expression of MMP-2 was positively correlated with the pathological stage and lymphatic metastasis (P <0.05), while the expression of TIMP-2 was negatively correlated with the expression of MMP-2 and TIMP-2 (P <0.05) . Conclusions The expressions of MMP-2 and TIMP-2 are closely related to the pathological stage and lymphatic metastasis of colorectal cancer, which can be used as a reference index to judge the biological behavior of colorectal cancer.