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以α,β-不饱和羰基结构为母体设计合成反丁烯二酸桂醇甲酯(CMF),并对反丁烯二酸桂醇甲酯的抗菌活性进行了研究。合成试验表明:以摩尔比为1∶2的马来酸酐与肉桂醇在95℃醇解反应2~4 h后加入异构化催化剂,90℃转型反应4 h后,添加6倍摩尔质量的甲醇,在90℃恒温反应4 h,反丁烯二酸桂醇甲酯的合成产率较高。皮肤刺激性试验表明:CMF对皮肤无致敏性。抗菌活性试验表明:反丁烯二酸桂醇甲酯不但杀菌谱广,而且有效作用浓度低,在食品加工、保藏中具有广阔的开发应用前景。
The α, β-unsaturated carbonyl structure as the parent design and synthesis of fumaric alcohol methyl ester (CMF), and anti-bacterial activity of fumaric acid methyl ester was studied. The synthesis test showed that the isomerization catalyst was prepared by the alcoholysis reaction of maleic anhydride and cinnamyl alcohol at the molar ratio of 1: 2 at 95 ℃ for 2 ~ 4 h, and the reaction was carried out at 90 ℃ for 4 h. Then, 6-fold molar mass of methanol , At a constant temperature of 90 ℃ for 4 h, the yield of methyl fumarate was higher. Skin irritation tests show that: CMF non-allergenic to the skin. Antibacterial activity tests showed that: methyl fumarate not only bactericidal spectrum, and the effective concentration of low, in food processing, preservation has broad prospects for the development and application.