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目的 观察血管内皮生长因子 (VEGF)在妊娠肝内胆汁淤积症 (ICP)胎盘中的表达。方法 采用免疫组织化学方法 ,检测 2 5例正常妊娠胎盘 (对照组 )和 2 5例ICP胎盘 (ICP组 )中VEGF的水平。结果 VEGF在正常妊娠胎盘和ICP胎盘中分布基本一致 ,分布在滋养细胞、血管及绒毛间质。在ICP组VEGF为轻度表达占 76% ,中度表达占 2 4% ,无重度表达 ;而在对照组VEGF轻度表达占 2 4% ,中度表达占 44 % ,重度表达占 3 2 %。ICP组中VEGF表达明显低于对照组 (P <0 .0 1)。结论 VEGF在胎盘中主要由绒毛滋养细胞分泌 ,ICP胎盘中VEGF的减少可能与胎盘血管生成减少及胎盘滋养叶细胞浸入异常有关 ,在ICP发病中占有一定的地位。
Objective To observe the expression of vascular endothelial growth factor (VEGF) in the placenta of intrahepatic cholestasis of pregnancy (ICP). Methods Immunohistochemistry was used to detect the levels of VEGF in 25 normal pregnant placenta (control group) and 25 ICP pregnant women (ICP group). Results The distribution of VEGF in normal pregnancy placenta and ICP placenta was basically the same, distributed in trophoblast, blood vessels and villus interstitial. In the ICP group, the expression of VEGF was mild in 76%, moderate in 24%, and no severe in VEGF, while mildly expressed VEGF in control group was 24%, moderately expressed 44%, and heavily expressed 32% . The expression of VEGF in ICP group was significantly lower than that in control group (P <0.01). Conclusions VEGF is mainly secreted by villous trophoblasts in the placenta. The decrease of VEGF in ICP placenta may be related to the decrease of placental angiogenesis and the imbalance of placental trophoblast cells, which play a certain role in the pathogenesis of ICP.