强直性脊柱炎(ankylosing spondylitis,AS)是以骶髂关节和脊柱慢性炎症为主的周身性疾病。其关节病理包括附着点炎和滑膜炎两种。实际上,这些病理过程是间质成分被水解蛋白酶消化的过程。近年来有研究显示,基质金属蛋白酶(MMP)-3是对基质起广泛作用的一种蛋白酶,其活性表现为降解聚集的核心蛋白、软骨连结蛋白纤维结合素, Ankylosing spondylitis (AS) is a systemic disease characterized by chronic inflammation of the sacroiliac joint and spine. The joint pathology, including attachment of inflammation and synovitis two. In fact, these pathological processes are the process by which the interstitial components are digested by hydrolytic proteases. In recent years, studies have shown that matrix metalloproteinase (MMP-3) is a protease that plays a broad role on the matrix, and its activity is manifested as degradative aggregation of the core protein, cartilage-associated protein fibronectin,