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妊娠期高血压疾病(HDCP)是孕产妇和围生儿发病及死亡的主要原因之一,容易造成不良围生结局。其病因至今尚未阐明,众多学者从多方面寻找原因,包括免疫系统的抗原异常反应结果、HDCP发病的遗传基因位点、胎盘或滋养细胞缺血缺氧导致一系列的病理生理改变、氧化应激引起的变化、某些营养成分的缺乏导致妊娠过程的异常等。该文主要探讨与研究较多的相关基因与因子的成果,为以后HDCP的病因研究提供思路。
Hypertensive disorders of pregnancy (HDCP) is one of the major causes of maternal and perinatal morbidity and mortality, which can easily lead to poor perinatal outcomes. Its etiology has not yet been elucidated. Many scholars look for reasons from many aspects, including the abnormal immune response of the immune system, HDCP genetic loci, placenta or trophoblast ischemia and hypoxia lead to a series of pathophysiological changes, oxidative stress Caused by changes in the lack of certain nutrients lead to abnormal pregnancy process. This article mainly discusses and studies the results of related genes and factors, providing ideas for the future study of the etiology of HDCP.