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目的探讨C反应蛋白(CRP)和IL-6在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)发病中的作用及经鼻持续气道正压通气(nCPAP)的治疗效果。方法对同期收治的30例OSAHS患者行nCPAP治疗,压力为8～16 cmH2O,治疗时间为8 h/晚,连续2个月,治疗前后采用ELISA法测定血清CRP与IL-6水平。设20例健康查体者为对照组。结果 OSAHS组治疗前后血清CRPI、L-6水平均显著高于对照组,其中治疗后显著低于治疗前(P均<0.05)。结论 CRP与IL-6可能共同参与了OSAHS的一系列病理变化过程;nCPAP治疗可明显降低OSAHS的炎症反应程度,对控制病情发展和并发症的发生具有重要意义。
Objective To investigate the role of C-reactive protein (CRP) and IL-6 in the pathogenesis of obstructive sleep apnea-hypopnea syndrome (OSAHS) and the therapeutic effect of nasal continuous positive airway pressure (nCPAP). Methods Thirty ASAHS patients treated at the same period were treated with nCPAP at a pressure of 8-16 cmH2O for 8 h / night for 2 consecutive months. Serum CRP and IL-6 levels were measured by ELISA before and after treatment. Set 20 cases of physical examination for the control group. Results Before and after treatment, the levels of CRPI and L-6 in OSAHS group were significantly higher than those in control group, and the levels of CRPI and L-6 in OSAHS group were significantly lower than those before treatment (all P <0.05). Conclusion CRP and IL-6 may participate in a series of pathological changes of OSAHS. NCPAP treatment can significantly reduce the degree of inflammatory response in OSAHS, which is important for controlling the progression of the disease and the occurrence of complications.