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1例83岁男性患者因慢性阻塞性肺疾病急性发作给予盐酸莫西沙星400 mg口服、1次/d。首次用药后约5 h患者双下肢出现散在红色皮疹伴瘙痒，第2天皮疹累及躯干部，双膝以下皮肤多发紫癜，实验室检查示血小板计数（PLT）1×10n 9/L，考虑为莫西沙星所致血小板减少症。停用该药，予止血、抗过敏、调节免疫功能、输注血小板等治疗。停药第2天，PLT 3×10n 9/L；停药第4天，PLT 35×10n 9/L。转上级医院后给予抗免疫反应、升血小板、止血等治疗5 d后，患者的PLT升至244×10n 9/L。n “,”An 83-year-old male patient received moxifloxacin hydrochloride (moxifloxacin) 400 mg once daily orally for acute attack of chronic obstructive pulmonary disease. He developed scattered red rashes, accompanied by itching, on his both lower limbs 5 hours after the first dose. Next day, the rashes involved skin on the trunk, and purpura appeared on the multiple skin below the knees. Laboratory tests showed platelet count (PLT) 1×10n 9/L, and thrombocytopenia related to moxifloxacin was considered. Moxi- floxacin was stopped and the treatments including hemostasis, anti-allergy, regulation of immune function, and platelet transfusion were given. On day 2 of drug withdrawal, his PLT was 3×10n 9/L, and on day 4 the PLT was 35×10n 9/L. He was transferred to a superior hospital and received the therapy including anti-immune response, platelet-raising, and hemostasis for 5 days. Then his PLT increased to 244×10n 9/L.n