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药物在体内的动态分布和机体对药物的反应常常受机体生物节律的影响,即机体生物节律性在药动学和药效学等方面表现出明显的差别,这在心血管系统药物显得尤为重要。许多疾病的发生是由于正常生理节律发生了异常节律,掌握人体疾病的节律变化并根据疾病的发病时间规律,结合药物的药动学、药效学等变化规律,设计出不同的给药时间和剂量方案,选择适合的剂型,进行时辰给药治疗,将减少药物的毒副作用,达到最佳疗效。
The dynamic distribution of drugs in the body and the body’s response to drugs are often affected by the biological rhythm of the organism, that is, the biological rhythms of the body show obvious differences in pharmacokinetics and pharmacodynamics, which are particularly important in the cardiovascular system drugs. Many diseases occur due to the abnormal rhythm of normal circadian rhythm and the rhythmic changes of human diseases. According to the regularity of disease onset, combined with the changes of the pharmacokinetics and pharmacodynamics of the drugs, the design of different dosing time and Dosage options, select the appropriate dosage form, the timing of treatment, will reduce the toxic side effects of drugs to achieve the best effect.