近年认为,动脉粥样硬化（AS）是由于动脉壁的内皮细胞和血管平滑肌细胞（VSMC）受多种危险因子的损伤而使机体产生的一种过度的炎症增生性反应过程,其中大量的生长因子、细胞因子和血管调节因子参与了此反应过程。低密度脂蛋白（LDL）发生氧化修饰形成氧化修饰低密度脂蛋白（OX-LDL）是AS发生发展的关键步骤,它可以通过调节多种细胞产生分泌多种细胞因子、生长因子发挥其致AS效应。本文就OX-LDL对AS发生发展关系较为密切的几种细胞因子、生长因子的影响加以阐述。 In recent years, atherosclerosis (AS) is thought to be caused by an excessive inflammatory proliferative reaction caused by damage to a variety of risk factors in the arterial wall endothelial cells and vascular smooth muscle cells (VSMCs), in which a large amount of growth Factors, cytokines and angiogenic factors are involved in this reaction. Oxidative modification of low density lipoprotein (LDL) to form oxidized low density lipoprotein (OX-LDL) is a key step in the development of AS. It can regulate many kinds of cells and produce many kinds of cytokines, effect. This article describes the impact of OX-LDL on the development of AS is closely related to several cytokines, growth factors.