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目的:探讨腹腔镜保留输卵管术后口服甲氨蝶呤预防持续性宫外孕的疗效。方法:选用150例宫外孕保守手术术后伴高危因素的患者分为3组:A组50例,口服甲氨蝶呤50mg/m2,2h1次,12次为一疗程;术后24h开始服用;B组50例,米非司酮100mg,2次/d共5d,术后24h开始服用;C组为对照组50例,保守性手术后未预防用药。治疗后常规监测。结果:A组未发生PEP,B组发生持续性宫外孕7例,发生率16%,C组%持续性宫外孕9例,发生率18%。两预防组低于非预防组的18%,A组与C组相比P<0.05,有显著性差异;B组与C组相比P>0.05,无显著性差异;3组无严重的副反应。结论:口服甲氨蝶呤能有效预防保留输卵管术后持续性宫外孕。
Objective: To investigate the efficacy of oral methotrexate after laparoscopic surgery to prevent persistent ectopic pregnancy. Methods: A total of 150 patients with conservative ectopic pregnancy after conservative surgery were divided into 3 groups: group A (n = 50), oral methotrexate 50mg / m2, 2h1 times, 12 times for one course of treatment; 50 cases, mifepristone 100mg, 2 times / d for 5 days, 24h after the start of taking; C group for the control group 50 cases, conservative surgery without prophylaxis. After treatment routine monitoring. Results: There was no PEP in group A, persistent ectopic pregnancy in group B occurred in 7 cases (16%) and in group C (9%), the incidence was 18%. The two preventive groups were lower than 18% of the non-prophylaxis group, P <0.05, there was a significant difference between A group and C group; P> 0.05, no significant difference between B group and C group; reaction. Conclusion: Oral methotrexate can effectively prevent persistent ectopic pregnancy after tubal retention.