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目的 探讨上皮型钙粘蛋白 (E cad)表达与大肠癌 (CLI)浸润转移的关系。方法 选取 6 0例原发性CLI组织及相应癌旁正常组织 ,用免疫组化SP法和抗E cad抗体检测观察E cad的表达。结果 CLI组织中E cad总阳性率 55% ,正常大肠上皮组织全部表达 ,E cad的表达与癌组织分化程度、生长方式、浸润深度、淋巴结转移密切相关 (P <0 .0 1)。结论 CLI组织E cad丧失或低表达是其获得浸润转移能力的因素之一。E cad可作为一种新的CLI标志物 ,其表达对判断预后有一定价值
Objective To investigate the relationship between the expression of E cad and invasion and metastasis of colorectal cancer (CLI). Methods Totally 60 cases of primary CLI tissues and adjacent normal tissues were selected. The expression of E cad was observed by immunohistochemical SP method and anti-E cad antibody. Results The positive rate of E cad in CLI tissue was 55%. The expression of E cad was closely related to the degree of differentiation, growth pattern, depth of invasion and lymph node metastasis (P <0.01). Conclusion The loss or low expression of E cad in the CLI tissue is one of the factors of its ability to obtain invasion and metastasis. E cad can be used as a new CLI marker, the expression of which has a certain value in judging the prognosis