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Richard Bright于1827年首先发现肾脏病患者血清呈乳白色,从而注意到肾功能不全与脂质代谢异常之间的关系。1917年,Epstein发现肾病综合征(NS)患者存在高胆固醇血症。目前认为。重度蛋白尿患者常伴有脂质异常,高脂血症是NS的一个临床特征。 NS患者脂质和脂蛋白异常 NS患者血浆甘油三酯(CG)和总胆固醇浓度升高。胆固醇成分中,极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)一般均升高。而高密度脂蛋白(HDL)和胆固醇浓度各家报告不一。Valeri等观察20例成人NS患者的HDL胆固醇,并与年龄、性别相仿的人群作对照,发现前者HDL胆固醇正常或降低。Sokolovskaya等发
Richard Bright first discovered in 1827 that patients with kidney disease had milky serum, noting the relationship between renal insufficiency and abnormal lipid metabolism. In 1917, Epstein found hypercholesterolemia in patients with nephrotic syndrome (NS). At present think. Patients with severe proteinuria are often associated with lipid abnormalities and hyperlipidemia is a clinical feature of NS. NS patients with abnormal lipid and lipoprotein NS patients with elevated plasma triglyceride (CG) and total cholesterol levels. Among the cholesterol components, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) are generally elevated. High density lipoprotein (HDL) and cholesterol concentrations reported differently. Valeri et al observed HDL cholesterol in 20 adult NS patients and compared them to age and sex-matched controls and found that HDL cholesterol was normal or decreased in the former. Sokolovskaya other hair