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2009年3月甲型H1N1流感病毒首次在北美被发现,并通过人际间传播引起了世界大流行,严重威胁人类健康,造成巨大经济负担。随着时间的推移,甲型H1N1流感病毒的基因不断发生变异,文章主要综述近年来甲型H1N1流感病毒的分子流行病学特征(遗传性、抗原性、致病性、致死性、耐药性以及糖基化位点等),以提高人们对甲型H1N1流感病毒变异可能导致的流感大流行的警惕。
The first influenza A (H1N1) virus was discovered in North America in March 2009 and caused a worldwide pandemic through interpersonal transmission, posing a serious threat to human health and causing a huge financial burden. With the passage of time, the gene of Influenza A (H1N1) virus continues to mutate. In this paper, the molecular epidemiological characteristics of H1N1 influenza virus (hereditary, antigenic, pathogenic, lethal, drug resistance Glycosylation sites, etc.) to raise awareness of the flu pandemic that may be caused by the mutation of the H1N1 virus.