论文部分内容阅读
目的:探讨食管癌患者术前、术后免疫状态的变化规律。方法:应用酶联免疫法检测了新疆 35例正常人、 5 0例食管癌患者术前、术后白细胞介素 - 2 (IL - 2 )、IL - 2受体 (IL - 2 R)、白细胞介素 - 6 (IL - 6 )、肿瘤坏死因子 -α(TNF-α)水平的动态变化值。 结果:新疆食管癌患者 IL - 2 R、IL - 6、TNF-α水平明显高于正常人 (P均 <0 .0 5 ) ,食管癌患者呈免疫抑制状态 ;患者自身术前、术后 1周比较发现 TNF- 2水平明显下降 ,而 IL - 6水平明显上升 (P均 <0 .0 5 )。结论:食管癌患者呈免疫抑制状态 ,手术切除肿瘤对患者是一个应激 ;1周内患者的免疫水平较紊乱 ;如何科学选择免疫治疗方案有待进一步的研究
Objective: To investigate the changes of immune status before and after esophageal cancer. Methods: Serum levels of interleukin - 2, interleukin - 2, interleukin - 2 (IL - 2R), leukocyte (IL - 6) and tumor necrosis factor - α (TNF - α) levels in serum were measured. Results: The levels of IL - 2R, IL - 6 and TNF - α in patients with esophageal cancer in Xinjiang were significantly higher than those in normal controls (all P <0.05). The patients with esophageal cancer were immunosuppressed. The patients’ The levels of TNF - 2 decreased significantly, but the level of IL - 6 increased significantly (P <0.05). Conclusion: Patients with esophageal cancer were immunosuppressed. Surgical resection of the tumor was a stress response to the patient. Immunocompromised patients were disordered within 1 week. Further study on how to select the immunotherapy should be further studied