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目的：探讨长期血液透析患者血清妊娠相关血浆蛋白A（PAPP－A）与微炎症状态的相关性。方法：以2014年12月至2015年1月在我院血液透析中心透析超过3月的患者89例为实验组，以健康体检者30例为对照组，比较两组的PAPP－A、超敏C反应蛋白（hCRP）、白介素－6（IL－6）及白蛋白（ALB）水平，分析PAPP－A与hCRP、IL－6及ALB的关系。结果：实验组PAPP－A、hCRP和IL－6水平均明显高于对照组（P＜0．05），ALB明显低于对照组（P＜0．05）；实验组hCRP、CRE、IL－6水平与血清PAPP－A浓度呈线性正相关（P＜0．05），ALB与PAPP－A浓度呈线性负相关（P＜0．05）。结论：长期血液透析患者血清PAPP －A 水平升高，且与微炎症状态密切相关。“,”Objective: To explore the correlation between serum pregnancy-associated plasma protein A (PAPP-A) and micro inflammation state in cases accepting long-term hemodialysis. Methods:89 cases accepting hemodialysis were set as the experimental group, and 30 healthy persons were set as the control group. PAPP-A, high sensitivity C reactive protein (hCRP), interleukin-6 (IL-6) and serum albumin (ALB) were compared in the two groups, and the correlation between PAPP-A and hCRP, IL-6, ALB was analyzed. Results: PAPP-A, hCRP and IL-6 levels in experimental group were significantly higher than those in the control group (all P<0.05), and ALB level in experimental group was significantly lower than that in the control group (P<0.05). Serum hCRP, CRE, IL-6 levels showed positive linear correlation with PAPP-A concentration , and serum ALB level showed negative linear correlation with PAPP-A concentration in experimental group(both P<0.05). Conclusions: PAPP-A level raise in case accepting long-term hemodialysis, and show close correlation to the micro inflammatory state.