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目的探讨层粘连蛋白(laminin,LN)在宫颈上皮内瘤样病变(CIN)及宫颈癌诊断中的作用及相关性。方法选取2014年5月至2016年5月间河北省廊坊市人民医院收治的120例宫颈病变患者为研究对象,选取同期体检的30例健康女性为对照组。采用磁微粒化学发光法检测入组受试者血清层粘连蛋白浓度,分析层粘连蛋白表达与宫颈上皮瘤样病变及宫颈癌之间的关系。结果 CINⅢ级患者血清层粘连蛋白浓度显著高于对照组,差异有统计学意义(P<0.05)。Ⅰ、Ⅱ和Ⅲ期浸润性宫颈癌患者层粘连蛋白浓度均显著高于对照组,差异均有统计学意义(均P<0.05)。高、中及低分化组患者血清层粘连蛋白浓度均显著高于对照组,差异均有统计学意义(均P<0.05)。从高分化到低分化,患者血清层粘连蛋白的浓度依次升高,组间比较,差异均有统计学意义(均P<0.05)。结论层粘连蛋白在宫颈上皮瘤样病变及宫颈癌患者中呈特异性的高表达,尤其在不同分化程度的宫颈癌中,表达差异明显,值得在临床上推广使用。
Objective To investigate the role and correlation of laminin (LN) in the diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods From May 2014 to May 2016, 120 cases of cervical lesions treated by the People’s Hospital of Langfang City, Hebei Province were selected as the research objects. 30 healthy women in the same period were selected as the control group. The serum microglia chemiluminescence method was used to detect the serum laminin concentration and analyze the relationship between laminin expression and cervical epithelial neoplasia and cervical cancer. Results The serum laminin concentration of patients with CIN Ⅲ was significantly higher than that of the control group (P <0.05). The laminin concentrations of patients with invasive cervical cancer in stage I, II and III were significantly higher than those in control group (all P <0.05). Serum laminin concentrations in patients with high, moderate and poorly differentiated tumors were significantly higher than those in controls (all P <0.05). From well-differentiated to poorly differentiated, the levels of serum laminin increased in turn, with statistical significance between the two groups (all P <0.05). Conclusion Laminin is highly expressed in patients with cervical epithelial neoplasia and cervical cancer, especially in differentiated cervical cancer. The expression of laminin is obviously different and is worth popularizing in clinic.