基质金属蛋白酶12(MMP-12),也被称为人巨噬细胞弹性蛋白酶,属含锌的内肽酶家族,参与多种生理过程,如血管重塑、纤维蛋白溶酶原的代谢、呼吸道炎症及重塑等。病理状态下MMP-12参与腹主动脉瘤、动脉粥样硬化、肺气肿、肿瘤、类风湿性关节炎、肝及肺纤维化等疾病的发生与发展。现就MMP-12在心血管疾病中的作用、机制与临床意义予以综述。 Matrix metalloproteinase 12 (MMP-12), also known as human macrophage elastase, is a family of zinc-containing endopeptidases that are involved in a variety of physiological processes such as vascular remodeling, metabolism of plasminogen, respiratory inflammation And remodeling. MMP-12 is involved in the occurrence and development of diseases such as abdominal aortic aneurysm, atherosclerosis, emphysema, cancer, rheumatoid arthritis, liver and pulmonary fibrosis under pathological conditions. Now on the role of MMP-12 in cardiovascular disease, mechanism and clinical significance are reviewed.