胃癌病机总属本虚标实、虚实夹杂.但在其不同临床阶段,病机却不尽相同,尤其在疾病晚期,临床表现复杂、变证蜂起,正虚、癌毒、痰浊、血瘀、水湿、气滞等胶结为患.本文基于临床实践,提出“阴虚痰凝毒结”是晚期胃癌的核心病机,认为胃阴不足为疾病进展之根本,痰凝毒结、聚散流窜为标,贯穿其始终.“,”Gastric cancer is one of the most common malignant tumors in China.Traditional Chinese medicine thinks the main pathogenesis of gastric cancer is root deficiency and branch excess,which always mix with each other.But in different clinical stages,the pathogenesis is not all the same.Especially in advanced disease,the clinical manifestations are complicated,changing constangtly;associated with healthy deficiency,cancerous toxin,phlegm,blood stasis,wet and Qi stagnation.Based on the clinical practice,this paper put forward the hypothesis “Yin deficiency combined with phlegm and toxin” is the core pathogenesis of advanced gastric cancer.The stomach yin-deficiency is the root of the progression of gastric cancer,while phlegm condensation and toxin retention as the standard,throughout the whole process.