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目的观察蒲元和胃胶囊联合三联疗法治疗幽门螺旋杆菌感染性慢性萎缩性胃炎的临床效果。方法将90例幽门螺旋杆菌感染性慢性萎缩性胃炎患者随机分为中药组(蒲元和胃胶囊)、中西药组(蒲元和胃胶囊+三联疗法)、西药组(三联疗法),每组30例。中药疗程为4周,西药疗程为10 d。服药前后行电子胃镜检查,并在病变最显著处取胃黏膜组织。观察3组患者服药前后胃黏膜炎性反应活动指数评分,临床症状改善情况及Hp感染情况,比较3组患者治疗总有效率。结果中西药组嗳气、纳差、胃痛、腹胀症状改善情况优于中药组和西药组(P<0.05);中西药组总有效率为96.7%,高于中药组的66.7%和西药组的50.0%(P<0.05)。中药组和西药组各症状改善情况、总有效率比较差异均无统计学意义(P>0.05)。结论中西医结合方法治疗幽门螺旋杆菌感染所致慢性萎缩性胃炎疗效显著,值得临床推广应用。
Objective To observe the clinical effect of Pu Yuan Hewei Capsule combined with triple therapy in treating Helicobacter pylori infection chronic atrophic gastritis. Methods Ninety patients with Helicobacter pylori infection of chronic atrophic gastritis were randomly divided into three groups: Chinese medicine group (Puyuanhewei capsule), Chinese and Western medicine group (Puyuanhewei capsule + triple therapy group) and Western medicine group (triple therapy group) 30 cases. Chinese medicine treatment for 4 weeks, western medicine treatment for 10 d. Before and after taking the electronic gastroscopy, and lesions in the most prominent place to take gastric mucosa. The gastric mucosal inflammatory response index, clinical symptom improvement and Hp infection were observed before and after taking the medication in three groups. The total effective rate of the three groups was compared. Results The improvement of asthma, anorexia, stomach pain and bloating symptom in Chinese and Western medicine groups was better than those in traditional Chinese medicine group and Western medicine group (P <0.05). The total effective rate in Chinese medicine group and western medicine group was 96.7%, higher than that in traditional Chinese medicine group (66.7% % (P <0.05). There was no significant difference in the improvement of symptoms between the traditional Chinese medicine group and western medicine group (P> 0.05). Conclusion Chinese and Western medicine treatment of Helicobacter pylori infection caused by chronic atrophic gastritis significant effect, worthy of clinical application.