在所有不育妇女中,3～10%是由于自发性黄体期缺陷而引起的。对年龄超过35岁,有习惯性流产史,或高泌乳素血症或使用促排卵药的病例,黄体期缺陷可高达50%。黄体不能产生足量的孕酮及类固醇来保证胚胎的种植及维持妊娠的需要,往往是由于垂体促性腺激素分泌异常而影响了卵泡的发育,使增殖期中雌激素分泌不足及颗粒细胞不能转变成黄体细胞,因此卵泡形成的异常影响了黄体的功能而造成不育。从近来的临床经验中发现有黄体缺陷的病人,卵泡期及黄体或血雌激素与孕酮在正常值以下,即 In all infertile women, 3 to 10% is due to defects in the spontaneous luteal phase. For patients over the age of 35, have a history of habitual abortion, or hyperprolactinemia or the use of ovulation drugs, luteal phase defects can be as high as 50%. The corpus luteum can not produce sufficient progesterone and steroids to ensure embryo cultivation and the need to maintain the pregnancy, which is often due to abnormal secretion of gonadotropin in the pituitary gland and affects the development of the follicle, which results in insufficient estrogen secretion during the proliferative phase and the inability of the granulosa cells to transform into Luteal cells, so the formation of abnormal follicles affect the function of the corpus luteum caused by infertility. From recent clinical experience found in patients with corpus luteum, follicular phase and luteal or blood estrogen and progesterone below normal, that