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肝脏是富有先天免疫反应细胞的重要器官,细胞因子在信号传导、转录调控、新血管形成等方面与肝细胞癌变关系极为密切。1.核因子-κB(NF-κB):NF-κB是一类普遍存在的、控制着各种基因转录的重要转录调节因子,促炎症细胞因子、病毒和紫外照射等细胞外的刺激都能引起NF-κB的激活。NF- κB的异常表达和激活与各种疾病的发生密切相关。缺失NF- κB的鼠肝脏,因肝细胞凋亡而出现退行性变,可见NF-κB信号通路在诱导生存基因抗细胞凋亡方面起重要作用。NF-κB通过NF-κB激活途径,抑制细胞凋亡,细胞抗凋亡作用的起动信号仍然是各种生存因子通过受体激酶的介导,激发以NF-κB 为中心的正向级联放大的信号转导通路,而参与肝细胞发生癌变过程。
The liver is an important organ rich in innate immune response cells, and cytokines are closely related to carcinogenesis of hepatocellular carcinoma in terms of signal transduction, transcriptional regulation and neovascularization. 1. Nuclear factor-κB (NF-κB): NF-κB is a ubiquitous and important transcriptional regulator that controls the transcription of various genes, and extracellular stimuli such as proinflammatory cytokines, viruses and ultraviolet radiation Causing NF-κB activation. Abnormal expression and activation of NF-κB are closely related to the occurrence of various diseases. Deletion of NF-κB in rat liver, due to hepatocyte apoptosis and degenerative changes, we can see NF-κB signaling pathway in the induction of survival genes play an important role in anti-apoptosis. NF-|ÊB through the NF-|ÊB activation pathway, inhibition of apoptosis, anti-apoptotic cell activation signal is still a variety of survival factors through the receptor kinase-mediated activation of NF-|ÊB as the center of the positive cascade amplification Of the signal transduction pathway, and involved in the occurrence of hepatocellular carcinoma process.