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目的 回顾近年来类固醇药物鼻腔局部应用的基础与临床研究进展。方法 分析近年有关的文献 2 6篇。结果 鼻腔局部用类固醇药物对参与变应性鼻炎和鼻息肉的多种细胞和细胞因子都有广泛的抑制作用 ,临床应用能有效地改善症状 ,治疗剂量下即使长期应用也几乎没有或无全身副作用 ,鼻腔局部副作用极轻微或无。结论 鼻腔局部用类固醇药物治疗鼻炎 (变应性和非变应性 )和鼻息肉等鼻腔疾病有广泛的应用前景。
Objective To review the basic and clinical research progress of topical nasal application of steroid drugs in recent years. Methods To analyze 26 related literatures in recent years. Results Topical nasal steroid drugs have a wide range of inhibitory effects on various cells and cytokines involved in allergic rhinitis and nasal polyps. Clinical application can effectively improve the symptoms, and there is little or no systemic side effects even at long-term therapeutic doses , Nasal local side effects are minimal or no. Conclusion Nasal topical steroid treatment of rhinitis (allergic and non-allergic) and nasal polyps and other nasal diseases have a wide range of applications.