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目的探讨高危型人乳头状瘤病毒(HPV)感染者血清硒、铜及叶酸含量的变化。方法用原子吸收光谱法检测217例HPV感染者(病例组)及106例HPV阴性者(对照组)血清中的硒、叶酸及铜含量。采用logistic回归t检验。结果HPV感染者血清硒、叶酸含量较非感染者低(P<0.05),铜含量两组无统计学差异(P>0.05)。结论新疆维吾尔族女性HPV感染的发生与硒、叶酸缺乏有关,HPV感染者适当的补充微量元素可能是治疗HPV感染的一种合理、有效的治疗手段。
Objective To investigate the changes of serum selenium, copper and folic acid in high risk human papillomavirus (HPV) infection. Methods Serum selenium, folic acid and copper in 217 cases of HPV infection (case group) and 106 cases of HPV negative (control group) were detected by atomic absorption spectrometry. Logistic regression t test was used. Results Serum selenium and folic acid levels in patients with HPV infection were lower than those in non-infected patients (P <0.05). There was no significant difference in copper content between the two groups (P> 0.05). Conclusions The incidence of HPV infection in Uighur women in Xinjiang is related to the deficiency of selenium and folic acid. Appropriate supplementation of trace elements in HPV-infected women may be a reasonable and effective treatment for HPV infection.