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腺苷一磷酸激活蛋白激酶(AMPK)是调控能量代谢的重要激酶,在代谢障碍、心血管疾病及肿瘤等疾病的病理进程中都有重要的调节作用。对AMPK的结构及其生理调节作用进行介绍,并重点综述AMPK间接激活剂和直接激活剂的研究进展,旨在为AMPK激活剂的深入开发提供参考。
Adenosine monophosphate-activated protein kinase (AMPK) is an important kinase that regulates energy metabolism and plays an important regulatory role in the pathological process of metabolic disorders, cardiovascular diseases and tumors. The structure and physiological regulation of AMPK are introduced, and the research progress of AMPK indirect activator and direct activator is reviewed. The aim is to provide a reference for the further development of AMPK activator.