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在9只雄性成年家兔及5只雄性成年犬的输精管内向附睾方向注入BCG,结果显示睾丸有明显的生精障碍(与对照组相比)。变化最显著的是变态期精子细胞和精母细胞,对间质细胞无明显影响。此结果说明在近附睾尾部的输精管内向附睾方向注射BCG可能是一种免疫避孕的方法。
BCG injection to the epididymis in the vas deferens of 9 male adult rabbits and 5 male adult dogs showed significant spermatogenic dysfunction in the testes compared with the control group. The most notable changes were metamorphosis of spermatids and spermatocytes, with no significant effect on stromal cells. This result suggests that injecting BCG into the epididymis in the vas deferens near the caudate epididymis may be an immunocontraceptive method.