To overcome the limitations of commercial CAD and handbook form of knowledge expression, the Distributed Knowledge Information System (DKIS) for product design is proposed. The structure of DKIS and the key issues in its implementation are introduced; the method of knowledge store and transfer of DKIS is discussed. The mechanism of knowledge representation, acquisition and utilization, based on Intet network, is achieved. Based on the concept of function driven, integrated Artificial Neural Networks and Active Server Pages techniques, transplanting the trained ANN into DKIS system, a new method for retrieving knowledge in DKIS over Intet is achieved. Finally, a prototype of DKIS is developed to demonstrate the feasibility of the structure and constructional method of DKIS. The work provides a scheme for speed knowledge acquisition and shortens the cycle of product development.