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目的 探讨Smac、Bcl-2、Survivin和Bax在早期子宫内膜癌(EC)中的表达与其预后的相关性.方法 选取20例正常子宫内膜者(NC组),31例子宫内膜不典型增生者(AEH组)及86例早期子宫内膜癌患者(EC组),采用免疫组化和Western blot检测Smac、Bcl-2、Survivin和Bax表达情况,Kaplan-Merei分析EC患者5年内生存状况,Cox风险比例模型分析预后影响因素.结果 免疫组化及Western blot检测结果显示,EC组Bcl-2、Survivin相对表达量显著高于NC组、AEH组,而Smac、Bax显著低于NC组、AEH组(P＜0.05);Kaplan-Merei法分析显示,Bcl-2、Survivin阴性者5年内生存时间和肿瘤无进展生存时间均显著高于Bcl-2、Survivin阳性者,而Smac、Bax阳性者5年内生存时间和肿瘤无进展生存时间均显著高于Smac、Bax阴性者(P＜0.05);Cox风险比例模型分析显示,发病年龄、肌层浸润深度、Smac、Bcl-2、Survivin和Bax为早期EC患者预后的影响因素.结论 Bcl-2、Survivin在早期子宫内膜癌组织中高表达,而Smac、Bax呈低表达,且均与患者预后生存显著相关.“,”Objective To explore the correlation between expressions of Smnac,Bcl-2,Survivin,Bax in early endometrial cancer and prognosis.Methods Immunohistochemical staining and Western blot were used to detect the expressions of Smac,Bcl-2,Survivin,and Bax in 20 women with normal endometrium (control group),31 patients with atypical endometrial hyperplasia (AEH group),and 86 patients with early endometrial cancer (EC group).Kaplan-Merei analysis was used to analyze five-year survival rate,Cox proportional haz-ard model was used to analyze the influencing factors of prognosis.Results Immunohistochemical staining and Western blot showed that the relative expression levels of Bcl-2 and Survivin in EC group were statistically significantly higher than those in control group and EH group (P＜0.05);the relative expression levels of Smac and Bax in EC group were statistically significantly lower than those in control group and EH group (P＜0.05).Kaplan-Merei analysis showed five-year survival rate and progression-free survival in patients with negative Bcl-2 and Survivin were statistically significantly higher than those in patients with positive Bcl-2 and Survivin (P＜0.05);five-year survival rate and progression-free survival in patients with positive Smac and Bax were statistically significantly higher than those in patients with negative Smac and Bax (P＜0.05).Cox proportional hazard model showed that age of onset,depth of myometrial invasion,Smac,Bcl-2,Survivin,and Bax were influencing factors of prognosis of early endometrial cancer patients.Conclusion Up-regulations of Bcl-2 and Survivin and down-regulations of Smac and Bax are significantly correlated with prognosis of patients with early endometrial cancer.