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癫(癎)是危害人类健康的常见神经系统疾病,临床常用抗癫(癎)药多通过细胞色素P450等肝药酶代谢.CYP3A4是P450酶系中最重要的代谢酶,参与40%～60%的药物代谢,与临床常用抗癫(癎)药的代谢也有非常紧密的关系.该文对CYP3A4的一般特性及其与抗癫(癎)药物的代谢研究进展作一概述.
肝药酶CYP3A4与抗癫(癎)药物的代谢研究进展
【摘 要】
：
癫(癎)是危害人类健康的常见神经系统疾病,临床常用抗癫(癎)药多通过细胞色素P450等肝药酶代谢.CYP3A4是P450酶系中最重要的代谢酶,参与40%～60%的药物代谢,与临床常用抗癫(癎)
【机 构】
：
重庆医科大学附属儿童医院神经内科
【出 处】
：
国际儿科学杂志
【发表日期】
：
2004年期
【基金项目】
：
重庆市卫生局资助项目;
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