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硝酸甘油能反射性引起心率加快和降低动脉血压,曾被认为不宜用于急性心肌梗死患者。近来证明,心肌梗死时应用某些血管舒张药可改善泵功能,减少心肌氧需量。本文报道14例急性心肌梗死病人,症状出现后12小时内含硝酸甘油0.3毫克的结果:5分钟后平均动脉压下降9毫米汞柱,肺楔状压从17毫米汞柱下降到12毫米汞柱,均可维持30分钟,心率增加,心搏工作指数(Stroke work index)减少。如心搏工作指数大于55克/平方米体表面积,含药后肺楔状压和心搏工
Nitroglycerin can cause reflex heart rate and reduce arterial blood pressure, was considered inappropriate for patients with acute myocardial infarction. Recently proved that the application of certain vasodilators myocardial infarction can improve pump function, reduce myocardial oxygen demand. This article reports 14 patients with acute myocardial infarction, the symptoms appear within 12 hours after the nitroglycerin 0.3 mg results: 5 minutes after the average arterial pressure decreased 9 mm Hg, wedge pressure decreased from 17 mm Hg to 12 mm Hg, Both maintained for 30 minutes with increased heart rate and reduced Stroke work index. Such as heart rate index greater than 55 grams / square meter body surface area, drug wedge pressure and heart rate