论文部分内容阅读
目的探讨经单鼻孔蝶窦入路垂体瘤切除术的并发症及相关发病因素。方法选择2006年7月至2014年3月间实施经单鼻孔蝶窦入路切除垂体瘤的178例垂体瘤患者,对其临床资料进行回顾性分析。结果 178例垂体瘤患者中,经单鼻孔蝶窦入路垂体瘤切除术治疗后,46例(25.8%)发生术后并发症,其中脑脊液漏8例(4.5%),鼻出血3例(1.7%),电解质紊乱4例(2.2%),尿崩症11例(6.2%),性功能低下13例(7.3%),视力减退3例(1.7%),颅内出血4例(2.2%)。单因素和多因素分析显示,术前内分泌紊乱、性欲降低、肿瘤≥3 cm与术后并发症的发生具有正相关性。结论术前积极纠正内分泌紊乱、综合评估肿瘤情况、提高术中操作技巧,能够降低术后并发症发生率。
Objective To investigate the complications and related factors of pituitary tumor resection via single nostril sphenoid sinus approach. Methods From July 2006 to March 2014, 178 patients with pituitary adenoma resected by single nostril sphenoid sinus approach were retrospectively analyzed. Results Of the 178 pituitary adenomas, postoperative complications occurred in 46 patients (25.8%) after single nostril pituitary tumor resection. Among them, 8 cases (4.5%) had cerebrospinal fluid leakage and 3 cases (2.2%), 11 cases of diabetes insipidus (6.2%), 13 cases of sexual dysfunction (7.3%), 3 cases of vision loss (1.7%) and 4 cases of intracranial hemorrhage (2.2%). Univariate and multivariate analysis showed that preoperative endocrine disorders, decreased libido, tumors ≥ 3 cm and postoperative complications have a positive correlation. Conclusion Preoperative correction of endocrine disorders, a comprehensive assessment of the tumor situation, improve intraoperative skills, can reduce the incidence of postoperative complications.