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研究证实,酒精性肝病的发生与肝组织中锌离子及其主要结合蛋白-金属硫蛋白的减少存在相关性。动物实验研究显示,补锌疗法可以用于预防处于急、慢性酒精暴露条件下所引起的肝损伤。补锌疗法可以保护消化道粘膜的完整性和预防内毒素血症的发生,由此避免了肝脏中内毒素诱导的肿瘤坏死因子-α生成。锌也可以直接阻止内毒素诱导的肿瘤坏死因子-α产生的信号途径。锌的这些肝内和肝外作用是不依赖金属硫蛋白的。然而,当金属硫蛋白过低时肝脏更易于发生酒精性损伤,并且当体内发生氧化应激时,高水平的金属硫蛋白可增强内源性锌离子的储存和释放。在预防和治疗酒精性肝病方面,锌可能成为一种高潜能的有效制剂。
Studies have confirmed that the occurrence of alcoholic liver disease and liver tissue zinc ion and its major binding protein - metallothionein reduction exists correlation. Animal studies have shown that zinc supplementation can be used to prevent liver damage caused by acute and chronic alcohol exposure. Zinc supplementation can protect the integrity of the mucosa of the digestive tract and prevent the development of endotoxemia, thereby preventing endotoxin-induced tumor necrosis factor-alpha production in the liver. Zinc can also directly block the endotoxin-induced signaling pathway of tumor necrosis factor-alpha production. These intrahepatic and extrahepatic effects of zinc are independent of metallothionein. However, the liver is more susceptible to alcoholic damage when the metallothionein is too low, and high levels of metallothionein enhance the storage and release of endogenous zinc ions when oxidative stress occurs in vivo. Zinc may become a highly potent and effective agent in the prevention and treatment of alcoholic liver disease.