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目的探讨有效治疗胃相关性扁平苔藓的方法。方法随机将60例口腔扁平苔藓并伴有胃病患者分为治疗组与对照组。对照组采用2%利多卡因加曲安奈德作黏膜下封闭,治疗组在封闭治疗的基础上,消除口腔及牙齿局部不利因素,并且给予补充维生素、钙制剂,给予复方铝酸铋胶囊(威安)治疗胃病,配合氯喹、白芍总苷及心理干预治疗,观察各组的有效率及复发率,观察外周血治疗前、后T淋巴细胞亚群的变化。结果治疗组总有效率为93.33%,对照组为90.00%,经统计学处理,差异无统计学意义(P>0.05)。随访1年治疗组复发率21.43%,对照组77.78%,统计学差异有统计学意义(P<0.01)。治疗后CD3、CD4、CD4/CD8升高,CD8降低。IgA、IgG含量变化差异有统计学意义(P<0.05)。结论采用系统治疗胃相关性口腔扁平苔藓是一种有效的治疗方法。
Objective To explore the effective treatment of gastric associated lichen planus. Methods A total of 60 patients with oral lichen planus complicated with stomach were randomly divided into treatment group and control group. The control group was treated with 2% lidocaine and triamcinolone acetonide for submucosal occlusion. On the basis of closed treatment, the treatment group eliminated the local adverse factors of oral cavity and teeth, supplemented with vitamins and calcium preparations, and given the compound bismuth aluminate capsule An) for the treatment of stomach, with chloroquine, total glucosides of paeony and psychological intervention, observe the effective rate and relapse rate in each group, observe the changes of T lymphocyte subsets in peripheral blood before and after treatment. Results The total effective rate was 93.33% in the treatment group and 90.00% in the control group. The difference was not statistically significant (P> 0.05). The follow-up 1-year treatment group 21.43% relapse rate, 77.78% in the control group, the statistical difference was statistically significant (P <0.01). After treatment CD3, CD4, CD4 / CD8 increased CD8 decreased. IgA, IgG content difference was statistically significant (P <0.05). Conclusion The systematic treatment of gastric related oral lichen planus is an effective treatment.