Agro-meteorological disasters(AMD) have become more frequent with climate warming. In this study, the temporal and spatial changes in the occurrence frequency of major meteorological disasters on wheat production were firstly explored by analyzing the observed records at national agro-meteorological stations(AMS) of China from 1991 to 2009. Furthermore, impact of climate change on AMD was discussed by comparing the warmer decade(2000–2009) with another decade(1991–2000). It was found that drought was the most frequent disaster during the last two decades, with a highest proportion of 79%. And the frequency of AMD increased significantly with climate change. Specifically, the main disasters occurred more frequently in the reproductive period than in the vegetative period. Besides, the spatial changes in the AMD frequency were characterized by region-specific. For example, the wheat cultivation areas located on the Loess Plateau and the middle-lower reaches of the Yellow River suffered mainly from drought. All these results were strongly linked to climate change in China. Therefore, sound adaptation options should be taken based on the latest changes of AMD under global warming to reduce agricultural damages. In this study, the temporal and spatial changes in the occurrence frequency of major meteorological disasters on wheat production were first explored by analyzing the observed records at national agro-meteorological stations (AMD) AMS) of China from 1991 to 2009. Further, impact of climate change on AMD was discussed by comparing the warmer decade (2000-2009) with another decade (1991-2000). It was found that drought was the most frequent disaster during the last two decades, with a highest proportion of 79%. And the frequency of AMD increased significantly with climate change. were characterized by region-specific. For example, the wheat cultivation areas located on the Loess Plateau and the middle-lower reaches of the Yellow River suffer All these results were strongly linked to climate change in China. All sound derived options should be taken based on the latest changes of AMD under global warming to reduce agricultural damages.