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目的 研究复方红芪提取液进行减方后对周围神经再生的作用。方法 建立钳夹损伤大鼠双侧坐骨神经的动物模型。按术后每日灌服药物的不同将 40只SD雄性大鼠随机均分为 4组。对照组 :灌服生理盐水 ;复方红芪组 :灌服复方红芪提取液 2ml ;减方组 :灌服复方红芪减方后提取液 2ml;补阳还五汤组 :灌服补阳还五汤 2ml。术后 2周及 4周 ,观察坐骨神经功能指数、运动神经传导速度及单位视野有髓神经纤维计数。结果 坐骨神经功能指数 :红芪组和减方组与对照组、红芪组与减方组的差异均有显著意义 (P >0 .0 5 ) ,且减方组优于红芪组 (P >0 .0 5 )。有髓神经纤维计数 :复方红芪组优于对照组 (P<0 0 1) ,减方组明显优于对照组 (P <0 .0 1) ,而红芪组与减方组间无显著差异。运动神经传导速度 :红芪组、减方组、补阳还五汤组与对照组相比 ,均优于对照组 (P <0 .0 5 ) ,但前 3组间无明显差异。结论 复方红芪减方提取液早期可以促进周围神经再生 ,药效更为专一 ,且优于传统方剂补阳还五汤。
Objective To study the effect of compound red yeast extract on the regeneration of peripheral nerve after reducing the prescription. METHODS: Animal models of bilateral sciatic nerves in rats with clamp injury were established. The SD male rats were randomly divided into 4 groups according to the daily administration of drugs. Control group: normal saline; compound red peony group: irrigating compound red peony extract 2ml; subtractive group: irrigating compound red peony root extract after extract 2ml; Buyang Huanwu decoction group: irrigating yang Five soup 2ml. At 2 and 4 weeks after surgery, the sciatic nerve function index, motor nerve conduction velocity, and myelinated nerve fiber count per unit field were observed. Results The sciatic nerve function index: There were significant differences between the red peony group and the decoction group and the control group, the red peony group and the decrement group (P > 0.05), and the decoction group was better than the red peony group (P > 0 .0 5 ). Myelinated nerve fiber counts:Compounded Radix Astragali was superior to control group (P<0.01), and decoction group was significantly better than control group (P < 0.01), but there was no significant difference between Radix Astragali and Radix Astragali membranaceus group. difference. The motor nerve conduction velocity: Compared with the control group, the red peony group, the decoction group, and Buyang Huanwu Decoction group were all superior to the control group (P < 0.05), but there was no significant difference among the first three groups. Conclusion The compound red peony root formula extract can promote the peripheral nerve regeneration in the early stage, and the efficacy is more specific, and is better than the traditional prescription Buyang Huanwu Decoction.