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目的:研究使用抗精神病药影响血糖代谢的特点。方法:198例未曾治疗或停药3个月以上的精神分裂症住院患者给予氯丙嗪或利培酮治疗。于入院时及治疗1、2、3和6个月时检测血糖浓度。结果:氯丙嗪组治疗2个月餐后2 h糖耐量试验(2hPG)、6个月后糖化血红蛋白(HbA1C)浓度均明显高于治疗前。治疗6个月血葡萄糖调节受损(IGR),氯丙嗪组有15.54%,利培酮组有7.37%;≥40岁者2hPG和HbA1C明显高于<40岁者。结论:2hPG和HbA1C浓度增高是糖代谢异常的早期表现,早期干预有利于防止IGR。
Objective: To study the use of antipsychotics to influence the characteristics of blood glucose metabolism. METHODS: 198 schizophrenic inpatients who did not receive treatment or were discontinued for more than 3 months were treated with either chlorpromazine or risperidone. Blood glucose levels were measured at admission and at 1, 2, 3, and 6 months of treatment. Results: The 2-h postprandial glucose tolerance test (2hPG) and the HbA1C concentration of 6-month post-treatment in chlorpromazine group were significantly higher than those before treatment. 6 months treatment of impaired glucose metabolism (IGR), chlorpromazine group 15.54%, risperidone group 7.37%; 2-year-old 40-year-old 2hPG and HbA1C were significantly higher than those <40 years. Conclusion: Increased concentrations of 2hPG and HbA1C are early manifestations of abnormal glucose metabolism, and early intervention is helpful to prevent IGR.