目的:观察阿霉素治疗顽固性恶性胸腔积液的疗效和不良反应。方法:21例顽固性恶性胸腔积液患者,向胸腔内1次性注入阿霉素30~40 mg,2~3 d后用细管闭式引流胸腔积液,观察临床疗效与不良反应。结果:21例顽固性恶性胸腔积液的有效率为95.24%,无明显不良反应。结论:胸水引流后腔内注入阿霉素,治疗顽固性恶性胸腔积液有较好的疗效且无复发,不良反应低。 Objective: To observe the efficacy and adverse reactions of doxorubicin in treatment of intractable malignant pleural effusion. Methods: Twenty-one patients with intractable malignant pleural effusion were infused intrapleurally with doxorubicin 30 ~ 40 mg for 2 ~ 3 days. The curative effect and adverse reactions were observed by closed drainage with pleural effusion. Results: The effective rate of 21 cases of intractable malignant pleural effusion was 95.24%, with no obvious adverse reaction. CONCLUSION: Adriamycin is injected intrathoracic drainage after pleural effusion, which has good curative effect and no recurrence in patients with refractory malignant pleural effusion. The adverse reactions are low.