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多环芳烃(PAHs)进入人体后能否引起癌变,部分决定于PAHs在体内的代谢情况。例如在酶的催化下,苯并(a)芘转变为酚、环氧化物和其它中间体,以及具有强致癌,致突活性的7,8——二氢二醇9,10环氧化物。这些致癌物再与细胞的DNA、RNA、蛋白质等大分子结合,引起组织发生癌变。国外学者研究表明胎盘有氧化、还原、水解、结合代谢药物的能力。人类胎盘中的AHH能将苯并(a)芘转变成7,8——二氢二醇9,10环氧化物。Weldh等发现吸烟惊人地提高了人肺和胎盘AHH的活性。Nebert等也发现吸烟妇女足月胎盘AHH
Polycyclic aromatic hydrocarbons (PAHs) into the human body can cause cancer, in part, depends on the metabolism of PAHs in the body. For example, under the catalysis of enzymes, benzo (a) pyrene is converted to phenols, epoxides and other intermediates, as well as 7,8-dihydrogenodiol 9,10 epoxide with potent oncogenic, inactivating activity. These carcinogens and then cell DNA, RNA, proteins and other macromolecules, causing tissue cancer. Foreign scholars have shown that the placenta oxidation, reduction, hydrolysis, combined with the ability of metabolic drugs. AHH in the human placenta converts benzo (a) pyrene to 7,8-dihydrogenated diol 9,10 epoxide. Weldh et al found that smoking dramatically raised the activity of human lung and placental AHH. Nebert et al also found that smoking women had full-term placental AHH