Hepatitis B Virus (HBV) is still one of the important problems threatening the health and safety of human life. If the virus can not be effectively controlled, it will gradually evolve into chronic hepatitis. Chronic hepatitis will not be treated for a long time, and will gradually develop into liver fibrosis, cirrhosis, liver cancer or even liver failure and other diseases with poor prognosis. However, there is no specific western medicine treatment for liver fibrosis, cirrhosis and other liver diseases. The main treatment methods are symptomatic treatment, internal medicine comprehensive treatment and prevention of complications. In recent years, the medical technology has been continuously developed and improved, scholars at home and abroad have focused on the effective ways to prevent and treat liver diseases. More and more studies have confirmed the mesenchymal stem cells Cell (MSC) plays an important role in the treatment of liver diseases. The author will describe the therapeutic effect of MSC from different sources on liver diseases.