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目的:研究吸入肝素对哮喘豚鼠气道炎症的影响,探讨肝素治疗哮喘的可能机制。方法:建立哮喘豚鼠模型,用肝素雾化吸入,观察支气管灌洗液(BALF)和支气管或细支气管壁的细胞成分变化。光镜和电镜下观察气道及肺组织病理变化。结果:肝素治疗组BALF中淋巴细胞、嗜酸性粒细胞、上皮细胞较哮喘模型组有显著减少(P<0.01),在支气管或细支气管壁,肝素治疗组肥大细胞数显著高于哮喘模型组(P<0.01),嗜酸性粒细胞有显著下降(P<0.01),光镜和电镜下气道损伤减轻。结论:肝素可以抑制哮喘豚鼠气道炎症,减轻哮喘豚鼠气道炎症损伤。
Objective: To study the effects of inhaled heparin on airway inflammation in asthmatic guinea pigs and to explore the possible mechanism of heparin in treating asthma. Methods: A guinea pig model of asthma was established and inhaled with heparin atomization to observe the change of cell components in bronchoalveolar lavage fluid (BALF) and bronchus or bronchiole. The pathological changes of the airways and lungs were observed under light microscope and electron microscope. Results: The number of lymphocytes, eosinophils and epithelial cells in the BALF of heparin treatment group was significantly lower than that of the asthma model group (P <0.01). The number of mast cells in the bronchial or bronchial wall and heparin treatment group was significantly higher than that in the asthma model group P <0.01), eosinophils decreased significantly (P <0.01), light and electron microscopy airway injury reduced. Conclusion: Heparin can inhibit airway inflammation in asthmatic guinea pigs and reduce airway inflammation in asthmatic guinea pigs.