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目的介绍并讨论甲状腺岛状癌的临床病理特征及鉴别诊断。方法结合免疫组化分析1例甲状腺岛状癌。结果癌细胞排列成巢状、岛屿状和条索状,细胞排列紊乱,呈圆形或椭圆形,形态较一致,细胞界限不清,胞质嗜酸性,偶见核分裂像,有血管侵犯。免疫组织化学标记TG阳性,CT、突触素(Syn)、癌胚抗原(CEA)均为阴性。结论甲状腺岛状癌的临床及病理特点介于高分化癌和未分化的间变性癌之间,需与甲状腺髓样癌、实性甲状腺乳头状癌、嗜酸细胞性滤泡癌、未分化癌及颈部大细胞淋巴瘤等鉴别。
Objective To introduce and discuss the clinicopathological features and differential diagnosis of thyroid island carcinoma. Methods One case of thyroid island carcinoma was analyzed by immunohistochemistry. Results Cancer cells arranged in nests, island-like and cord-like, disordered cells, round or oval, more consistent morphology, cell boundaries, eosinophilic cytoplasm, occasional mitotic image, vascular invasion. Immunohistochemical markers of TG positive, CT, synaptophysin (Syn), carcinoembryonic antigen (CEA) were negative. Conclusions The clinical and pathological features of thyroid island carcinoma are between well-differentiated and undifferentiated anaplastic carcinomas, and need to be related to medullary thyroid carcinoma, solid papillary thyroid carcinoma, eosinophilic follicular carcinoma, undifferentiated carcinoma And neck large cell lymphoma and other identification.