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目的探讨超声自动乳腺全容积成像(ABVS)联合彩色多普勒血流显像(CDFI)对乳腺癌新辅助化疗(NCT)疗效评价的临床意义。方法选取2013年9月至2016年3月间沧州中西医结合医院收治的行NCT治疗的64例乳腺癌患者,系统性回顾患者的临床资料,分析所有患者化疗前后原发病灶成像及血流特点。结果临床医师查体后诊断与病理学结果一致。ABVS+CDFI检查有效52例,无效12例,诊断敏感度83.3%,符合率为62.5%。患者NCT化疗前后肿瘤长度、宽度、厚度及面积和体积大小比较,差异均有统计学意义(均P<0.05)。患者化疗前后肿瘤边界清晰度、内部回声及后方回声比较,差异均有统计学意义(均P<0.05)。有效组患者中,化疗前后0~Ⅰ级和Ⅱ~Ⅲ级血流患者所占比例比较,差异均有统计学意义(均P<0.05);无效组患者中,化疗前后0~Ⅰ级和Ⅱ~Ⅲ级血流患者所占比例比较,差异均无统计学意义(均P>0.05)。患者化疗前后血流最大流速(Vmax)和阻力指数(RI)比较,差异均有统计学意义(均P<0.05)。结论 ABVS和CDFI评价乳腺癌患者行NCT后临床疗效各有优势,两者结合具有更好地准确性和科学性,可作为临床评价乳腺癌患者NCT疗效的首选方法。
Objective To investigate the clinical significance of ultrasound total breast ultrasound (ABVS) combined with color Doppler flow imaging (CDFI) in evaluating the efficacy of neoadjuvant chemotherapy (NCT) for breast cancer. Methods Sixty-four breast cancer patients treated with NCT from September 2013 to March 2016 in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected. The clinical data of the patients were retrospectively reviewed. The imaging and blood flow characteristics of the primary lesion before and after chemotherapy were analyzed . Results Clinic examination after physical examination and pathological findings. 52 cases were effective in ABVS + CDFI examination, 12 cases were ineffective, the diagnostic sensitivity was 83.3% and the coincidence rate was 62.5%. The tumor length, width, thickness, area and volume of patients before and after NCT chemotherapy were significantly different (all P <0.05). Before and after chemotherapy in patients with tumor border sharpness, internal echo and echo after the comparison, the difference was statistically significant (P <0.05). Among the patients in the effective group, the proportion of patients with grade 0 ~ Ⅰ and grade Ⅱ ~ Ⅲ before and after chemotherapy were significantly different (all P <0.05). Among the patients in the ineffective group, the levels of 0 ~ Ⅰ and Ⅱ ~ Ⅲ grade blood flow in the proportion of patients, the difference was not statistically significant (P> 0.05). Before and after chemotherapy in patients with maximum flow velocity (Vmax) and resistance index (RI), the differences were statistically significant (P <0.05). Conclusion ABVS and CDFI evaluate the clinical efficacy of breast cancer patients after NCT has its own advantages, the combination of the two has a better accuracy and scientific, as a clinical evaluation of breast cancer patients with NCT efficacy of the preferred method.