目的:探讨原发性干燥综合征(pSS)误诊为多发性硬化(MS)原因。方法:回顾性分析9例误诊为MS的pSS患者的资料。结果:误诊与pSS的症状缺乏特异性、血清学检查不平行及医师对pSS影像表现及实验室检查认识局限。结论:应结合详细的病史、体格检查及实验室检查来明确诊断。 Objective: To investigate the causes of misdiagnosis of primary s syndrome (SS) as multiple sclerosis (MS). Methods: The data of 9 patients with misdiagnosed MS were retrospectively analyzed. Results: The symptoms of misdiagnosis and pSS were lack of specificity. The serological tests were not parallel and physicians’ understanding of pSS imaging findings and laboratory tests were limited. Conclusion: Should be combined with detailed medical history, physical examination and laboratory tests to confirm the diagnosis.