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目的观察稳心颗粒联合银杏达莫注射液治疗冠心病心绞痛对患者血液流变学的影响。方法将冠心病心绞痛患者80例随机分为2组,各40例。对照组采用稳心颗粒治疗,观察组则在对照组治疗的基础上加用银杏达莫注射液治疗,比较2组临床疗效,治疗前后心绞痛发生次数和持续的时间及血液流变学指标的变化。结果观察组总有效率为87.50%显著高于对照组的65.00%(P<0.05);治疗后2组心绞痛发作次数少于治疗前,持续时间短于治疗前,且观察组优于对照组(P<0.05);治疗后2组CRP、全血黏度、血浆黏度及纤维蛋白原水平均低于治疗前,且观察组低于对照组(P<0.05)。结论稳心颗粒联合银杏达莫注射液可有效控制冠心病心绞痛患者的病情,使血液流变学指标恢复正常,可明显缓解患者的临床症状,对改善患者冠状动脉供血及供氧具有重要的作用,在临床应用中值得推广。
Objective To observe the effect of Wenxin granule combined with Yinxingdamo injection on hemorheology in patients with coronary heart disease. Methods 80 patients with coronary heart disease angina pectoris were randomly divided into two groups, 40 cases each. The control group was treated with Wenxin Granules, while the observation group was treated with Yinxingdamo Injection on the basis of the control group. The clinical curative effect, the number of angina pectoris and the duration of the treatment and the changes of hemorheology indexes were compared . Results The total effective rate in the observation group was 87.50%, which was significantly higher than that in the control group (65.00%, P <0.05). The incidences of angina pectoris in the two groups were less than those before treatment, the duration was shorter than that before treatment, and the observation group was better than the control group P <0.05). After treatment, CRP, whole blood viscosity, plasma viscosity and fibrinogen level in two groups were lower than before treatment, and the observation group was lower than the control group (P <0.05). Conclusion Wenxin Granule combined with Yinxingdamo injection can effectively control the condition of patients with angina pectoris and make the indexes of hemorheology return to normal, which can obviously relieve the clinical symptoms of patients and have an important effect on improving coronary blood supply and oxygen supply , Worth promoting in clinical application.