新生儿硬肿症是新生儿时期尤其是早产儿常见的疾病之一 ,重症者常并发多器官功能衰竭。据有关资料统计 ,本病发病率仅次于新生儿肺炎 ,占新生儿住院人数的第二位 ,病死率高达 40 %～ 5 0 % [1] 。为降低病死率 ,减少并发症 ,近年来多主张在新生儿硬肿症的治疗中早期应用抗凝剂? Neonatal scleredema is one of the common diseases in neonatal period, especially in premature infants. Severe cases often have multiple organ failure. According to statistics, the incidence of this disease is second only to that of neonatal pneumonia, accounting for the second highest number of newborns hospitalized with a case fatality rate of 40% to 50% [1]. In order to reduce mortality and reduce complications, in recent years many advocate the treatment of neonatal sclera early application of anticoagulants?