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目的:调查消化门诊人群胃食管反流病(gastroesophageal reflux disease,GERD)生活质量状况.方法:针对安徽铜陵三家市级医院2008-06/08消化内科门诊连续就诊人群,根据国内通用的GERD临床诊断标准(RDQ总积分≥12分)和洛杉矶反流性食管炎(RE)内镜诊断标准进行GERD调查和诊断.采用中文版SF-36生存质量量表进行GERD患者生活质量状况地评估.所有调查资料使用Epi Data3.0软件建立数据库,利用SPSS13.0做统计学分析.根据数据的分布特征,分别采用χ2检验、非参数检验、两样本t检验.结果:三家市级医院消化内科门诊7352例连续就诊患者中共调查诊断出GERD199例.187例GERD患者实际参与了生活质量状况的调查,选取了374例同年龄同性别的正常健康人群进行了病例对照研究.结果显示,GERD病例组8个纬度生活质量评分、SF-36量表总分均明显低于健康对照组,有显著性差异(P<0.05).非糜烂性反流病(nonerosive reflux disease,NERD)组7个纬度生活质量评分、SF-36量表总分均明显低于反流性食管炎(reflux esophagitis,RE)组患者,有显著性差异(P<0.05).无论NERD或RE组女性患者生活质量量表总分均明显低于男性,有显著性差异(P<0.05).结论:GERD患者生活质量较正常健康人群明显下降;在NERD、女性患者中更为突出.精神心理因素可能在GERD发病中起到一定作用.
Objective: To investigate the quality of life of patients with gastroesophageal reflux disease (GERD) in the digestive outpatient population.Methods: According to the clinical diagnosis of GERD in three public hospitals in Tongling City, Anhui Province from June 2008 to June 2008, (RDQ total score≥12 points) and Los endorectal esophagitis (RE) endoscopy diagnostic criteria for GERD investigation and diagnosis of quality of life using the Chinese version of the SF-36 quality of life questionnaire GERD assessment.All the survey Data were analyzed using Epi Data3.0 software.Statistical analysis was done by using SPSS13.0.According to the distribution characteristics of data, we used χ2 test, non-parametric test and two-sample t test.Results: 7352 cases of digestive medicine clinic in three municipal hospitals 189 consecutive GERD patients were diagnosed in GERD patients.One hundred and seventy seven GERD patients were actually involved in the investigation of quality of life, and 374 healthy controls of the same age were enrolled in the case-control study.The results showed that eight latitudes Quality of life score, SF-36 total score were significantly lower than the healthy control group, there was a significant difference (P <0.05). Non-erosive reflux disease (noneros ive reflux disease (NERD) group had significant difference (P <0.05) between 7 latitude quality of life score and SF-36 total score in patients with reflux esophagitis (RE) The total score of quality of life scale of female patients in NERD or RE group was significantly lower than that in male patients (P <0.05) .Conclusion: The quality of life of GERD patients is obviously lower than that of normal healthy people, and more prominent in NERD and female patients Psychiatric factors may play a role in the pathogenesis of GERD.