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目的:以丹参素为指标,检测丹参素钠与丹参注射液的组织分布,初步探讨丹参注射液中其他成分对丹参素体内分布的影响。方法:小鼠随机分为2组,分别腹腔注射丹参素钠和丹参注射液(含丹参素60 mg.kg-1),给药后30 m in处死,HPLC测心、肝、脾、肺、肾等组织丹参素浓度,比较2组差异。结果:丹参素浓度从大到小,丹参素钠组依次为C肾>C脾>C肺>C心>C肝,丹参注射液组依次为C肾>C肺>C脾>C心≈C肝。心、肝、脾、肾等组织丹参素浓度2组间均有差异。结论:丹参注射液中其他成分可影响丹参素的体内分布。
OBJECTIVE: To determine the tissue distribution of sodium danshensu and Salvia Miltiorrhiza Bunge by using Danshensu as an index, and to explore the effects of other components of Salvia miltiorrhiza on the in vivo distribution of Danshensu. Methods: The mice were randomly divided into 2 groups: intraperitoneal injection of sodium danshensu and Danshen injection (containing Danshensu 60 mg.kg-1), 30 min after administration, Kidney and other organizations Danshensu concentration, the difference between the two groups. Results: Danshensu concentration from big to small, Danshensu sodium group followed by C kidney> C spleen> C lung> C heart> C liver, Danshen injection group followed by C kidney> C lung> C spleen> C heart ≈C liver. Heart, liver, spleen, kidney and other organizations Danshensu concentrations were different between the two groups. Conclusion: The other components of Danshen injection can affect the distribution of Danshensu in vivo.