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近年来,国外一些学者经体外研究发现,维生素K_3(又名甲萘醌,简写为VK_3)可以抑制肿瘤细胞的生长,但它对在休肿瘤的作用如何,以及其作用机制是否与其它醌类抗肿瘤药相同,尚未知晓。本文对此进行了研究。实验使用昆明种小鼠,雄性,按常规方法移植小鼠肉癌Sai瘤细胞悬液后随机分组。24h后,开始ip不同剂量的VK_3(分别为5、10、20、40和80mg/kg·d~(-1)),对照组ip等体积的生理盐水,每日1次,13d,第14天处死小鼠,取出肿瘤称重后,计算“肿瘤抑制率”,并测定了其内超氧化物歧化酶(SOD)和脂质过氧代谢产物丙二醛(MDA)的含量.
In recent years, some foreign scholars found in vitro studies, vitamin K_3 (also known as menaquinone, abbreviated as VK_3) can inhibit the growth of tumor cells, but its role in Hugh tumor, and its mechanism of action and other quinones The same antitumor drugs have not been known. This article has carried on the research. Kunming mice were used in the experiment, and male mice were randomly divided into groups according to the conventional method. After 24h, different dose of VK_3 (5, 10, 20, 40 and 80 mg / kg · d ~ (-1)) and normal saline in the control group were given once a day, The mice were sacrificed and the tumors were removed. The tumor inhibition rate was calculated and the contents of superoxide dismutase (SOD) and malondialdehyde (MDA), a lipid peroxidation product, were measured.