Orthogonal frequency division multiplexing(OFDM)which has been adopted in the long-term evolution(LTE)system can improve the system capacity obviously.However,it also brings about severe inter-cell interference(ICI)for cell-edge users(CEUs).To tackle this problem,multi-user selection and power control(MuS-PC)is proposed as an efficient scheme in uplink coordinated multi-point multi-user multi-input multi-output(CoMP-MU-MIMO)transmission/reception.This paper jointly considers user’s signal to interference plus noise ratio(SINR)and proportional fairness(PF)to maximize the total channel capacity in multi-user selection by formulating a penalty function.To simplify the penalty function’s computation,particle swarm optimization(PSO)algorithm is introduced.In addition,power control is adopted to maximize overall energy efficiency.Simulation results demonstrate that the MuS-PC scheme can not only obtain the optimal total channel capacity while guarantee each user’s quality of service(QoS)and PF,but also largely reduce computational complexity and improve energy efficiency.As a result,the poor communication quality of CEUs can be enhanced. Orthogonal frequency division multiplexing (OFDM) which has been adopted in the long-term evolution (LTE) system can improve the system capacity obviously. Yet, it also brings about severe inter-cell interference (ICI) for cell-edge users .To tackle this problem, multi-user selection and power control (MuS-PC) is proposed as an efficient scheme in uplink coordinated multi-point multi-user multi-input multi-output (CoMP-MU- MIMO) transmission / reception. This paper jointly considers user’s signal to interference plus noise ratio (SINR) and proportional fairness (PF) to maximize the total channel capacity in multi-user selection by formulating a penalty function. To simplify the penalty function’s computation, particle swarm optimization (PSO) algorithm is introduced.In addition, power control is adopted to maximize overall energy efficiency. Simulation results demonstrate that the MuS-PC scheme can not only obtain the optimal total channel capacity while guarantee each user’s quality of service (Qo S) and PF, but also largely reduce computational complexity and improve energy efficiency. As a result, the poor communication quality of CEUs can be enhanced.