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本文报道使用正常免疫力小鼠肾包膜下移植的方法(SRC)测定人软组织肉瘤对化疗药物的敏感性。经病理组织学证实的软组织肉瘤15例中,药敏结果可评价的有12例约为80％(12/15),略高于国外学者报告的63％(17/27)的肉瘤SRC法测敏的可评价率。在可评价的12例中有4例所施用的各种药物均不敏感约占33％(4/12)。仅对其中一种药物敏感的有3例约占25％(3/12)。在我们利用SRC法测定的软组织肉瘤化疗药物敏感率中ADM、DDP、DTIC、CTX与国内外医疗单位近年来报告的相同,单药化疗软组织肉瘤的有效率基本相同P>0.05。基于我们的实验结果,我们认为如果能在软组织肉瘤化疗前进行SRC法测敏,有可能减少临床盲目用药带来的副作用,增加化疗效果。同时我们认为SRC法在测定软组织肉瘤化疗药物敏感性上,具有一定实用性和可靠性。本文中就SRC法测敏中敏感药物评价标准也进行了讨论。
This paper reports the sensitivity of human soft tissue sarcoma to chemotherapeutic drugs using normal immune mice subrenal transplantation method (SRC). Of the 15 cases of soft tissue sarcomas confirmed by histopathology, 12 cases were evaluated for drug susceptibility, about 80% (12/15), slightly higher than the SRC assay for sarcomas (63%) reported by foreign scholars (17/27). Sensitive rate. Of the 12 evaluable cases, 4 were insensitive to approximately 33% (4/12) of all drugs administered. Only 3 of the 2 cases (3/12) were sensitive to one of the drugs. The ADM, DDP, DTIC, and CTX in the susceptibility rate of the soft tissue sarcoma chemotherapeutic drugs measured by the SRC method are the same as those reported by medical organizations at home and abroad in recent years. The single-agent chemotherapy soft tissue sarcoma has the same effective rate (P>0.05). Based on our experimental results, we believe that if the SRC assay can be performed prior to chemotherapy in soft tissue sarcoma, it may reduce the side effects of clinical blind use of drugs and increase the effect of chemotherapy. At the same time, we believe that the SRC method has certain practicality and reliability in the determination of the sensitivity of chemotherapy drugs in soft tissue sarcoma. This article also discusses the evaluation criteria for sensitive drugs in the SRC method.