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目的总结黄连素药理作用以及在新剂型方面的研究进展,为黄连素新剂型开发提供参考。方法通过阅读大量近几年黄连素在新剂型研制和临床应用方面的文献,对黄连素的新剂型研究进展进行总结概述。结果黄连素新剂型能拓展其临床应用领域,已成为中药研发的热点。结论对黄连素新剂型进行深入的生物药剂学和药动学研究,改善其理化性质,对减少其不良反应,改善药物疗效具有重要意义。
OBJECTIVE To summarize the pharmacological effects of berberine and its research progress in new dosage forms, and to provide a reference for the development of new dosage forms of berberine. Methods By reading a large number of recent years berberine in the development of new formulations and clinical applications of the literature, the research progress of berberine new formulations summarized. Results berberine new formulations can expand its clinical applications, has become a hot research and development of Chinese medicine. Conclusion In-depth biopharmaceutical and pharmacokinetic studies of berberine new formulations to improve their physico-chemical properties are of great significance in reducing their adverse reactions and improving the efficacy of the drug.